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KMID : 0351619690100010171
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Kyungpook Medical Journal
1969 Volume.10 No. 1 p.171 ~ p.175
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hippuric Acid Synthesis and Biliary Excretion of Sulfobromophthaleine in Rats after Partial Hepatectomy
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Abstract
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Recovery of detoxifing and excretory functions of residual liver after partial hepatectomy (removed a´oout 70~/,~ of total liver) were studied by determining the detc:~ication of benzoic acid, as measured by the urinary excretion of hippuric acid, anyd biliary excretion of sulfobromo phthaleine.
In evaluating tha detoxication function, the ratio of urinary hippurate -C^14 to benzoate-C14 (H/B ratio) was also esti,::ated by thin layer chromatography after administration of sodium benzoate-C14 as a more significant criterion of the function than the amount of urinary hippurate (Choi and Ryoo: Kyungpook Med. J., 10:145, 1969).
Immediately after the partial hepatectomy, urinary H/B ratio showed about 2/5 of normal rats while the amount of urinary hippurate was decreased only to 2/3 of normal. The reduction of ]7/B ratio was more significant on 12 days pose: hepatectomy and gradually recovered through liver regeneration. Biliary excretion of intravenously in;ected sulfobromophthaleine also revealed more decrease ~2 days post-hepatectomy than immediate after the operation, but on 4 days post-hepatectomy the exretory function was alriost completely recovered.
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